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*** Ivermectin may not just be the anti-parasitic, anti-cancer, anti-viral repurposed drug we recognise but may have multiple other neuroprotective benefits for humanity in an era where we all may be subjected to neurotoxins – some apparent like vaccines and others invisible like electromagnetic frequencies (“EMFs”). – Expose-news.com Ivermectin for Parkinson’s Disease – MS, Stroke, Chronic Pain, Anxiety, Depression, and Schizophrenia? Modulated through P2X4 ReceptorsBy Dr. Justus R. Hope We all should know that ivermectin is effective not only against river blindness but can be repurposed against many different types of cancer, even against metastatic disease. During the 2020 pandemic, ivermectin saved many lives worldwide, and not just in the Intensive Care Unit. Ivermectin has also been used to treat long covid and long vaxxed patients by eminent physicians like Dr. Pierre Kory. Some people, like yours truly take ivermectin weekly for its protective or preventative effects. When you consider the broad spectrum of its anti-disease activity in combination with its vast safety profile, why would you not? Ivermectin is not only anti-parasitic, but it is anti-viral, anti-bacterial and anti-cancer. But today we know there is more and much more. Dr. William Makis recently wrote about how ivermectin has properties of promoting remyelination in demyelinating diseases like multiple sclerosis. However, ivermectin has long been known to have potential effectiveness against motor neuron disorders like ALS or Lou Gehrig’s disease. Ivermectin has shown such great promise against ALS, a patent application was filed by Belgian scientists in 2007. “Use of ivermectin and derivates thereof for the treatment of amyotrophic lateral sclerosis’ (Publication No.: WO/2008/034202A3), to cover the use of ivermectin and analogues, to prevent, retard and ameliorate a motor neuron disease such as amyotrophic lateral sclerosis and the associated motor neuron degeneration.” There is emerging evidence that ivermectin may be effective not just against ALS, but against a variety of neurological disorders including Parkinsonism, a disease that many link with the mRNA injections.  Courtesy FLCCC SubstackIvermectin exerts much of its neuroprotective effects by modulating P2X4.
“Because of its action on P2X4 receptors, ivermectin has potential with respect to preventing alcohol use disorders[92] as well as for motor neuron disease.[93]” As an aside, ivermectin reverses the effect of alcohol on P2X4 and has the potential to reduce cravings and consumption of alcoholic beverages in those afflicted with substance use disorder. However, back to neuroprotection. “Ivermectin (IVM), a positive modulator of P2X4Rs, enhanced levodopa (L-DOPA)-induced motor behaviour. Thus, IVM is increasing striatal dopamine release through enhanced cholinergic activity on dopamine terminals.” If it is neuroprotective, and the evidence is growing that it is, and humanity is being bombarded with various toxins and electromagnetic frequencies each day that compromise our nervous system, perhaps there is reason to consider ivermectin as a neuro-protective repurposed drug worthy of use during this dangerous time in our history. Ivermectin’s main mechanism of action in neuroprotection seems to be its stabilisation of P2X4 receptors. “Ivermectin is a positive allosteric modulator of P2X4 that stabilises this subunit in the open state [20], which consequently may also prevent P2X4 internalisation [21, 22].” Why is the stabilisation of P2X4 so important? Because overexpression of P2X4 is not only a disease driver in ALS and Parkinsonism, it plays a key role in many other diseases including Multiple Sclerosis, Alzheimer’s Disease, Chronic Neuropathic Pain, Migraine, Epilepsy, Alcohol Use Disorder, Depression, Bipolar, Schizophrenia and Anxiety. Or to put it more technically, this study explains the pathological role of P2X4: “In various pathological states, such as trauma, ischemia, chronic pain, neurodegenerative processes and several neuropsychiatric disorders, de novo expression of P2X4 and/or an increase in cell surface P2X4 density has been reported in microglia and/or neurons, thus suggesting possible key and multiple roles of neuronal and microglial P2X4 receptors in the establishment and/or maintenance of these pathologies [25]. Changes in the intracellular expression of P2X4 may also have important consequences in the pathophysiological context.” The following study on the effect of allosteric modulators on P2X4 – like ivermectin – highlighted its potential effectiveness in neuroprotection. “Collectively it appears that there is good evidence that positive allosteric modulation of P2X2, P2X4, and P2X7 receptors may be of therapeutic benefit in a number of different conditions summarised in Figure 2. It is also clear that there may be endogenous molecules, particularly in the central nervous system, that could act as positive modulators to enhance the action of the physiological agonist ATP (e.g., neurosteroids on P2X2 and P2X4).” Ivermectin may not just be the anti-parasitic, anti-cancer, anti-viral repurposed drug we recognise but may have multiple other neuroprotective benefits for humanity in an era where we all may be subjected to neurotoxins – some apparent, and others invisible like EMF. About the AuthorJustus R. Hope is a writer’s pseudonym for a medical professional and author who has written extensively on the topics of medicine, health and disease. He graduated summa cum laude from Wabash College and earned his medical degree from Baylor College of Medicine. He also completed a residency in Physical Medicine & Rehabilitation at The University of California Irvine Medical Centre. He has practised medicine for over 35 years and maintains a private practice in Northern California. Dr. Hope has written several books, including ‘Ivermectin for the World’, ‘Surviving Cancer, Covid-19, and Disease: The Repurposed Drug Revolution’ and ‘Ivermectin for Freedom’. His work focuses on the use of repurposed drugs to treat various diseases, including cancer and covid-19. He publishes articles on a Substack page titled ‘Repurposed Drugs: Powers & Possibilities’ which you can subscribe to and follow HERE. 2ND SMARTEST GUY IN THE WORLD JUL 2, 2023 331 100 Share This Substack has recently written about the wonder drugs Ivermectin and Fenbendazole: BACK IN STOCK: PetDazole: Pharmaceutical Grade Pure Fenbendazole 2ND SMARTEST GUY IN THE WORLD · JUN 21 Very limited quantities of PetDazole are back in stock. Read full story Ivermectin May Defeat Cancer and Other Common Chronic Diseases of Aging 2ND SMARTEST GUY IN THE WORLD · JUN 15 This Substack recently wrote about the powerful anticancer properties of Fenbendazole: I also mentioned in passing that one of reasons Ivermectin was so viciously maligned and suppressed was that if society were taking it to cure PSYOP-19 one of the side effects would be “sudden” plummeting cancer rates, and thus BigPharma et al. went all out to destroy … Read full story As a combination therapy these two drugs offer a highly synergistic approach to curing a wide range of ailments from slow kill bioweapon injection damage to prior-based diseases to (turbo) cancers, etc. https://www.2ndsmartestguyintheworld.com/p/synergistic-pairing-of-ivermectin?utm_campaign=post&utm_medium=web For decades, we have been forced to rely on information from corrupt and ignorant media sources. Mainstream media, in turn, is dictated by corporate and political agendas whose only function is to improve their bottom line, at the cost of our life, liberty, and happiness. When a global health crisis threatened to worsen a situation that has long been out of our control, a group of doctors, entrepreneurs, pharmacists, and scientists decided to fight back. No longer would we sit back and swallow the prevailing “wisdom” without doing our own critical thinking. Nor would we swallow the medicines that they told us were safe, without proving their efficacy beyond a reasonable doubt. Instead, we looked past the lies and the coverups, to well-known medical traditions and health modalities. Deep expertise in modern pharmacy, functional medicines, and cutting edge research has served as our North Star. We research, develop, and test health modalities that help people take control over their own lives again. The result is Early Treatment LLC. Our products are created with only the most premium components. Our medicines are vetted and have decades-long, stellar safety records. Our treatments are developed and compounded for you, to ensure maximum efficacy. Our goal is to help humanity prepare for the worst, so we can live our best lives without fear. https://www.earlytreatmentmeds.com/about-us Premium Wellness Products  Ivermectin, a common anti-parasite drug, has shown great efficacy in the fight against covid-19. For the first time, medical researchers have documented how ivermectin docks to the SARS-CoV-2 spike receptor-binding domain that is attached to the ACE2 receptor. In this way, ivermectin effectively inhibits viral attachment and replication, assisting a precise antiviral response that can target the SARS-CoV-2 spike protein at its most advantageous cleavage site. The researchers showed how ivermectin interferes with the attachment of the spike protein to the human cell membrane. Ivermectin is a simple medicine derived from the bacterium Streptomyces avermitilis. It weakens and kills parasites by interfering with their nervous system and muscle function. Ivermectin targets the glutamate-gated chloride channels in the parasite’s nerve and muscle cells, bolstering inhibitory effects in the parasite’s own neurotransmission. As the chloride ions permeate, the parasite’s cells are hyper-polarized and then paralyzed, resulting in their demise. In this study, ivermectin docked in region of leucine 91 of the spike protein and at the histidine 378 of the ACE2 receptor. The binding energy and constancy of ivermectin was also measured and found to be sufficient at the ACE2 receptor, proving the anti-parasitic molecule a powerful force for blocking viral attachment of SARS-CoV-2. Ivermectin blocks SARS CoV-2 at the ACE2 receptor in humansThe 17 randomized controlled trials that use ivermectin for early treatment and prophylaxis report positive effects, with an estimated improvement of 73 percent and 83 percent, respectively. Out of 37 early treatment and prophylaxis studies for ivermectin, 97 percent report positive effects. One of the studies documents how ivermectin inhibits the replication of SARS-CoV-2 in vitro and displays broad-spectrum anti-viral activity against the causative virus (SARS-CoV-2). This study showed a 5,000-fold reduction in viral RNA after just 48 hours. The study also proves that effective treatments and prophylactics can mitigate the replication and spread of a virus thousands of times faster than the paranoid, isolationist approach of social distancing and lockdowns. If antivirals were encouraged early and often, then the spread of actual infectious virus would have been mitigated at rates thousands of times faster than the insane method of treating everyone as if they are infectious. By treating actual infections where symptoms are present, the spread is reduced at magnitudes thousands of times greater, while conveying immunity instead of terror. The SARS-CoV-2 spike protein is designed to attach to angiotensin-converting enzyme 2 (ACE2) in humans. To see whether ivermectin could dock at this receptor site and block viral attachment, the researchers used a program called AutoDock Vina Extended. This docking study showed the crystal structure of the SARS-CoV-2 spike receptor binding domain. The researchers looked specifically at the human ACE2 receptor and calculated the root-mean-square deviation (RMSD) of its atomic positions. A lower RMSD value indicates a more accurate docking capacity. When the RMSD value is three or greater, no docking has occurred at the receptor site. Ivermectin did not dock at nine of the locations; however, it did dock at the leucine 91 region of the spike and histidine 378 at the intersection of proteins between SARS CoV-2 and the ACE2 receptor complex. Previous studies proved ivermectin’s efficacy, but had to use high concentrations of the drug because the study relied on African green monkey kidney epithelial cells, which do not express the human ACE2 receptor. SARS-CoV-2 is specifically equipped to infect human ACE2 receptors, so this study could prove ivermectin to be effective in much smaller dosages. Clinical trials are now underway to determine if ivermectin is an effective treatment for covid-19. The global conspiracy to suppress effective anti-viral medicinesThe World Health Organization, the FDA, and the NIH have repeatedly suggested that no antiviral treatments exist for covid-19, even though multiple antiviral herbs and drugs have been studied during previous SARS and MERS epidemics and found to be effective. This time around, many of these antivirals were used with great effectiveness by doctors who were willing to go out on a limb and save lives. Chinese hospitals used various antiviral herbs to treat covid-19 patients. These hospitals studied the effects of the herbs for impeding virus-cell receptor binding, for stimulation of the host’s immunity, for blocking virus entry into host cells through action on the host’s enzymes, and for prevention of SARS-CoV-2 RNA synthesis and replication. The research found numerous phytochemicals to be effective, including: quercetin, ursolic acid, kaempferol, isorhamnetin, luteolin, glycerrhizin, and apigenin. The top three most effective plants for treating covid-19 included licorice root, (Glycyrrhiza glabra) chicory root, (Cichorium intybus) and hibiscus flowers (Hibiscus sabdariffa). A number of antiviral plants contain compounds that target all three antiviral targets, including olive leaf (Olea europaea), white horehound (Marrubium vulgare), black cumin seed (Nigella sativa), garden cress (Lepidium sativum), Judean wormwood (Artemisia Judaica), guava (Psidium guajava), chrysanthemum (Glebionis coronaria), and Maryam’s flower (Anastatica). Medical systems around the world are not properly equipped to strengthen the human immune response or understand what individuals need to overcome an infection. When it comes to fighting infections, the US FDA and European drug regulators parrot the same narrative of ignorance and apathy, withholding viable antivirals from the public. By the way, this is the only legal way to bring experimental vaccines to the global marketplace, by proving that no effective treatments exist. This suppression of science on antiviral treatments has paved the way for emergency use authorization of experimental vaccines and forced countless patients to suffer (and die) on ventilators, without treatment. Learn more about this new ivermectin study: Lance D Johnson
Sources include: NCBI.NLM.NIH.gov IVMMeta.com NCBI.NLM.NIH.gov DrEddyMD.com DrEddyMD.com Bitchute.com |
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